Small Cell Lung Cancer (SCLC)

Understanding Small Cell Lung Cancer (SCLC)

Small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. These cancers usually develop near the centre of the lungs in the bronchi, and invade nearby tissues and lymph nodes. SCLC is also referred to as oat cell carcinoma because the cancer cells look flat under a microscope.

SCLC behaves quite differently from NSCLC and is more aggressive. The cancer cells divide more rapidly to form large tumours that can spread throughout the body before being detected.

Normal Cells vs SCLC Cells:

Small cell lung cancer (SCLC) is sometimes called “oat-cell carcinoma” because the cells appear flat under the microscope.

Small cell lung cancer (SCLC) is sometimes called “oat-cell carcinoma” because the cells appear flat under the microscope.

The Two Stages of SCLC:

There are two stages of small cell lung cancer: limited-stage small cell lung cancer and extensive-stage small cell lung cancer. The treatment plan for each stage is different.

Limited-Stage Small Cell Lung Cancer (LS-SCLC)

With LS-SCLC, SCLC is usually found in only one lung, and may also be found in the lymph nodes in the chest and those near the collarbones. Treatment usually begins with a combination of chemotherapy and radiation, potentially followed by surgery (in rare cases).

Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

With ES-SCLC, the cancer has spread to both lungs, or to distant lymph nodes and organs. Treatment will consist of chemotherapy or a combination of chemotherapy and immunotherapy first. Radiation may be used as a palliative option.